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KMID : 1161420110140070866
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Journal of Medicinal Food
2011 Volume.14 No. 7 p.866 ~ p.869
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In vitro Amoebicidal Activity of Borage (Borago officinalis) Extract on Entamoeba histolytica
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Leos-Rivas Catalina
Verde-Star M. Julia
Torres Lidia Osuna
Oranday-Cardenas Azucena
Rivas-Morales Catalina
Barron-Gonzalez M. Porfiria
Morales-Vallarta Mario R.
Cruz-Vega Delia E.
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Abstract
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Borage (Borago officinalis) is a plant with nutritional value that is also used in traditional medicine to treat gastrointestinal disease. This study investigated the amoebicidal activity of a methanol extract of borage. The 50% inhibitory concentration (IC50) of the extract for Entamoeba histolytica was 33?μg/mL. The 50% lethal dose of the extract for brine shrimp was greater than 1,000?μg/mL. The IC50 of the extract for Vero cells was 203.9?μg/mL. These results support the use of borage to prevent diseases associated with E. histolytica infection.
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KEYWORD
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Boraginaceae, brine shrimp, cytotoxicity, traditional medicine
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